主題：Modelling the potential role of engineered symbiotic bacteria in malaria control
主要內容：A recent experimental study suggests that the engineered symbiotic bacteria Serratia AS1 may provide a novel, effective and sustainable biocontrol of malaria. These recombinant bacteria have been shown to be able to rapidly disseminate throughout mosquito populations and to efficiently inhibit development of malaria parasites in mosquitoes in controlled laboratory experiments. In this talk, I will report a recent work in which we develop a climate-based malaria model which involves both vertical and horizontal transmissions of the engineered Serratia AS1 bacteria in mosquito population. We show that the dynamics of the model system is totally determined by the vector reproduction ratio $R_v$, and the basic reproduction ratio $R_0$. If $R_v \le 1$, then the mosquito-free state is globally attractive. If $R_v>1$ and $R_0\le 1$, then the disease-free periodic solution is globally attractive. If $R_v>1$ and $R_0>1$, then the positive periodic solution is globally attractive. Numerically, we verify the obtained analytic result and evaluate the effects of releasing the engineered Serratia AS1 bacteria in field by conducting a case study for Douala, Cameroon. We find that ideally, by using Serratia AS1 alone, it takes at least 25 years to eliminate malaria from Douala. This implies that continued long term investment is needed in the fight against malaria and confirms the necessity of integrating multiple control measures.
專家姓名：Zou Xingfu
工作單位：加拿大西安大略大學
專長和學術成就：研究興趣為微分方程和動力系統的理論及應用，特別是反應擴散方程、常泛函微分方程及偏泛函微分方程及其在生物領域的應用
專家簡介：鄒幸福教授分別在中山大學，湖南大學和約克大學（York University， Canada）獲得學士，碩士和博士學位，并在維多利亞大學（University of Victoria, Canada）和佐治亞理工(Georgia Institute of Technology, USA) 從事過博士后研究工作。曾任教于加拿大紐芬蘭紀念大學（Memorial University of Newfoundland, Canada）, 現為加拿大西安大略大學（University of Western Ontario）應用數學系的教授。
時間：2021-01-05 10:00:00
地點：線上